Speckled ANA pattern is associated with which antibodies?

Speckled ANA pattern is associated with which antibodies?

• A. anti-centromere
• B. anti-Sm and anti-RNP
• C. anti-dsDNA
• D. anti-histone

Answer: (B)

ANA patterns on indirect immunofluorescence reflect antibodies against specific nuclear targets. The speckled pattern arises from antibodies directed at extractable nuclear antigens that are part of ribonucleoprotein complexes. The most characteristic associations for this pattern are anti-Smith and anti-RNP antibodies, which produce the granular, speckled nuclear staining seen with ENA antibodies. Other antibodies tend to show different patterns: anti-centromere gives a centromere (bar-code) pattern and is linked to limited scleroderma; anti-dsDNA and anti-histone often yield a homogeneous (diffuse) staining pattern. Thus, the speckled pattern best aligns with anti-Smith and anti-RNP.

ANA patterns on indirect immunofluorescence reflect antibodies against specific nuclear targets. The speckled pattern arises from antibodies directed at extractable nuclear antigens that are part of ribonucleoprotein complexes. The most characteristic associations for this pattern are anti-Smith and anti-RNP antibodies, which produce the granular, speckled nuclear staining seen with ENA antibodies.

Other antibodies tend to show different patterns: anti-centromere gives a centromere (bar-code) pattern and is linked to limited scleroderma; anti-dsDNA and anti-histone often yield a homogeneous (diffuse) staining pattern. Thus, the speckled pattern best aligns with anti-Smith and anti-RNP.