RBCs characterized by semicircular area removed by the spleen and indent margins are called?

RBCs characterized by semicircular area removed by the spleen and indent margins are called?

• A. Bite cells
• B. Heinz bodies
• C. Spherocytes
• D. Target cells

Answer: (A)

The correct concept is that of bite cells. This appearance arises when the spleen removes (pits) denatured hemoglobin fragments called Heinz bodies from red blood cells. The removal leaves a semicircular indentation, giving the distinct “bite” taken out of the cell and a margin that looks indented. Bite cells are classically seen in oxidative stress conditions such as G6PD deficiency, where Heinz bodies form and are selectively removed by the spleen. To place the others in context: Heinz bodies are the intra‑erythrocyte inclusions themselves, not the indented cells. Spherocytes are RBCs that have lost membrane and become spherical, with reduced or absent central pallor. Target cells have a bullseye appearance with a central, pigmented area surrounded by a pale zone and a peripheral ring. The description specifically matches the bite cell morphology.

The correct concept is that of bite cells. This appearance arises when the spleen removes (pits) denatured hemoglobin fragments called Heinz bodies from red blood cells. The removal leaves a semicircular indentation, giving the distinct “bite” taken out of the cell and a margin that looks indented. Bite cells are classically seen in oxidative stress conditions such as G6PD deficiency, where Heinz bodies form and are selectively removed by the spleen.

To place the others in context: Heinz bodies are the intra‑erythrocyte inclusions themselves, not the indented cells. Spherocytes are RBCs that have lost membrane and become spherical, with reduced or absent central pallor. Target cells have a bullseye appearance with a central, pigmented area surrounded by a pale zone and a peripheral ring. The description specifically matches the bite cell morphology.