Leukemoid reaction can be triggered by which of the following?

Leukemoid reaction can be triggered by which of the following?

• A. Heat stroke
• B. Sleep deprivation
• C. Vitamin deficiency
• D. Allergen exposure

Answer: (D)

A leukemoid reaction is a large, reactive increase in white blood cells driven by systemic inflammation or stress, not a malignancy. When the body encounters a strong inflammatory stimulus, such as an allergen exposure, inflammatory mediators stimulate the bone marrow to release neutrophils and even immature forms, producing marked leukocytosis with a left shift. This mirrors the pattern seen in severe infections or inflammatory states, so allergen exposure can trigger the reactive WBC rise. Heat stroke can cause stress-related leukocytosis, but it’s not the classic trigger for a leukemoid pattern; sleep deprivation and vitamin deficiencies don’t typically cause this kind of acute, marked neutrophilic response.

A leukemoid reaction is a large, reactive increase in white blood cells driven by systemic inflammation or stress, not a malignancy. When the body encounters a strong inflammatory stimulus, such as an allergen exposure, inflammatory mediators stimulate the bone marrow to release neutrophils and even immature forms, producing marked leukocytosis with a left shift. This mirrors the pattern seen in severe infections or inflammatory states, so allergen exposure can trigger the reactive WBC rise.

Heat stroke can cause stress-related leukocytosis, but it’s not the classic trigger for a leukemoid pattern; sleep deprivation and vitamin deficiencies don’t typically cause this kind of acute, marked neutrophilic response.