Four cryoprecipitate units have AHF and fibrinogen values; which action is appropriate?

Four cryoprecipitate units have AHF and fibrinogen values; which action is appropriate?

• A. discard all units
• B. put units 1, 2, and 3 in inventory, discard unit 4
• C. put all units in inventory
• D. put units 1 and 2 in inventory, discard units 3 and 4

Answer: (C)

Testing cryoprecipitate for antihemophilic factor (Factor VIII) activity and fibrinogen content ensures the product will be capable of helping patients with bleeding issues. If each unit has documented AHF activity (Factor VIII) and fibrinogen levels that meet the required release criteria, there is no reason to discard them. All four units should be placed in inventory for storage and potential transfusion, because they meet the potency standards. Discarding any would ignore valid quality criteria, and releasing only some would not reflect that all units meet the required potency. Cryoprecipitate is specifically used to supply Factor VIII and fibrinogen, so units with these components above the minimum thresholds are appropriate for inventory.

Testing cryoprecipitate for antihemophilic factor (Factor VIII) activity and fibrinogen content ensures the product will be capable of helping patients with bleeding issues. If each unit has documented AHF activity (Factor VIII) and fibrinogen levels that meet the required release criteria, there is no reason to discard them. All four units should be placed in inventory for storage and potential transfusion, because they meet the potency standards. Discarding any would ignore valid quality criteria, and releasing only some would not reflect that all units meet the required potency. Cryoprecipitate is specifically used to supply Factor VIII and fibrinogen, so units with these components above the minimum thresholds are appropriate for inventory.