Alder-Reilly anomaly is characterized by which finding?

Alder-Reilly anomaly is characterized by which finding?

• A. Coarse cytoplasmic granules in neutrophils and monocytes
• B. Hypersegmented neutrophils
• C. Absent granules in granulocytes
• D. Platelet inclusion bodies

Answer: (A)

Alder-Reilly anomaly is a leukocyte storage disorder in which neutrophils and monocytes contain large, coarse azurophilic granules in their cytoplasm. These granules are lysosomal storage material from defective degradation of mucopolysaccharides, seen in mucopolysaccharidoses. This distinctive granule appearance in neutrophils and monocytes is what defines the finding. Hypersegmented neutrophils occur in megaloblastic anemia and not this condition, while absence of granules or platelet inclusion bodies point to other disorders.

Alder-Reilly anomaly is a leukocyte storage disorder in which neutrophils and monocytes contain large, coarse azurophilic granules in their cytoplasm. These granules are lysosomal storage material from defective degradation of mucopolysaccharides, seen in mucopolysaccharidoses. This distinctive granule appearance in neutrophils and monocytes is what defines the finding. Hypersegmented neutrophils occur in megaloblastic anemia and not this condition, while absence of granules or platelet inclusion bodies point to other disorders.